Proteomics

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A non-canonical vitamin K cycle is a potent ferroptosis suppressor


ABSTRACT: Raw files corresponding to LC-MS-based relative quantification of oxidized lipids in Pfa1 cells and mouse liver samples subjected to ferroptosis. Data were acquired in parallel reaction monitoring (PRM) MS/MS mode.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Maria Fedorova  

PROVIDER: MSV000089489 | MassIVE | Thu May 19 04:58:00 BST 2022

REPOSITORIES: MassIVE

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Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid peroxidation<sup>1</sup>, has a key role in organ injury, degenerative disease and vulnerability of therapy-resistant cancers<sup>2</sup>. Although substantial progress has been made in understanding the molecular processes relevant to ferroptosis, additional cell-extrinsic and cell-intrinsic processes that determine cell sensitivity toward ferroptosis remain unknown. Here we show that the fully reduced forms of vitam  ...[more]

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