Dataset Information

GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins

ABSTRACT: Mass Spectrometry data pertaining to manuscript entitled, "GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins"

INSTRUMENT(S): Orbitrap Fusion Lumos, nanoACQUITY UPLC

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Phillip D. Zamore

PROVIDER: MSV000089490 | MassIVE | Thu May 19 05:38:00 BST 2022

SECONDARY ACCESSION(S): PXD033999

REPOSITORIES: MassIVE

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GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins.

Arif Amena A Bailey Shannon S Izumi Natsuko N Anzelon Todd A TA Ozata Deniz M DM Andersson Cecilia C Gainetdinov Ildar I MacRae Ian J IJ Tomari Yukihide Y Zamore Phillip D PD

Nature 20220630 7923

Argonaute proteins use nucleic acid guides to find and bind specific DNA or RNA target sequences. Argonaute proteins have diverse biological functions and many retain their ancestral endoribonuclease activity, cleaving the phosphodiester bond between target nucleotides t10 and t11. In animals, the PIWI proteins-a specialized class of Argonaute proteins-use 21-35 nucleotide PIWI-interacting RNAs (piRNAs) to direct transposon silencing, protect the germline genome, and regulate gene expression dur ...[more]

PMID: 35772669

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