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Lack of TRPV1 Channel Modulates Mouse Gene Expression and Liver Proteome with Glucose Metabolism Changes

ABSTRACT: To investigate the role of the transient receptor potential channel vanilloid type 1 (TRPV1) channel in hepatic glucose metabolism, we performed proteomics analysis of the liver of C57Bl/6J (WT) and Trpv1 KO mice (n = 4 per group). Liver from Trpv1 KO mice showed significant proteomics changes consistent with enhanced glycogenolysis, as well as increased gluconeogenesis and inflammatory features.

INSTRUMENT(S): maXis

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Jose Thalles Lacerda Maria Nathalia Moraes

PROVIDER: MSV000089696 | MassIVE | Tue Jun 21 13:20:00 BST 2022

SECONDARY ACCESSION(S): PXD034801

REPOSITORIES: MassIVE

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