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Drug Induced Liver Injury Biomarker Discovery Data

ABSTRACT: Discovery proteomics was conducted on serum samples using tandem mass tagging for relative quantitation to discover potential new biomarkers of DILI.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Mireia Fernandez Ocana

PROVIDER: MSV000089782 | MassIVE | Fri Jul 01 04:48:00 BST 2022

REPOSITORIES: MassIVE

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Publications

Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans.

Ravindra Kodihalli C KC Vaidya Vishal S VS Wang Zhenyu Z Federspiel Joel D JD Virgen-Slane Richard R Everley Robert A RA Grove Jane I JI Stephens Camilla C Ocana Mireia F MF Robles-Díaz Mercedes M Isabel Lucena M M Andrade Raul J RJ Atallah Edmond E Gerbes Alexander L AL Weber Sabine S Cortez-Pinto Helena H Fowell Andrew J AJ Hussaini Hyder H Bjornsson Einar S ES Patel Janisha J Stirnimann Guido G Verma Sumita S Elsharkawy Ahmed M AM Griffiths William J H WJH Hyde Craig C Dear James W JW Aithal Guruprasad P GP Ramaiah Shashi K SK

Nature communications 20230303 1

Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. Here, we identify, confirm, and replicate the biomarker performance characteristics of candidate proteins in patients with DILI at onset (DO; n = 133) and follow-up (n = 120), acute non-DILI at onset (NDO; n = 63) and follow-up (n = 42), and healthy volunteers (HV; n = 104). Area under the receiver operating characteristic curve (AUC) f ...[more]

PMID: 36869085

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