Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 6600
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932)
SUBMITTER: Prof. Dr. Markus Ralser
PROVIDER: MSV000090136 | MassIVE | Mon Aug 15 11:06:00 BST 2022
SECONDARY ACCESSION(S): PXD036062
REPOSITORIES: MassIVE
Messner Christoph B CB Demichev Vadim V Muenzner Julia J Aulakh Simran K SK Barthel Natalie N Röhl Annika A Herrera-Domínguez Lucía L Egger Anna-Sophia AS Kamrad Stephan S Hou Jing J Tan Guihong G Lemke Oliver O Calvani Enrica E Szyrwiel Lukasz L Mülleder Michael M Lilley Kathryn S KS Boone Charles C Kustatscher Georg G Ralser Markus M
Cell 20230419 9
Functional genomic strategies have become fundamental for annotating gene function and regulatory networks. Here, we combined functional genomics with proteomics by quantifying protein abundances in a genome-scale knockout library in Saccharomyces cerevisiae, using data-independent acquisition mass spectrometry. We find that global protein expression is driven by a complex interplay of (1) general biological properties, including translation rate, protein turnover, the formation of protein compl ...[more]