Proteomics

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Aprosoff,Dyakov_2022_SLX4_BioID

ABSTRACT: This dataset consists of 18 raw MS files and associated peak lists and result files, acquired on a TripleTOF 6600 mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Camila Aprosoff and Vivian Chung. Streptavidin affinity purification, mass spectrometric acquisition, and data analysis was performed by Boris Dyakov. The files are associated with a manuscript submitted for publication by Aprosoff et al. that identifies proteins associated with SLX4 using BioID. The AP-MS dataset contained in this manuscript was separately uploaded to MassIVE by Cassandra Wong (Gingras Lab). Haley Wyatt is the corresponding author of the manuscript (haley.wyatt@utoronto.ca). Anne-Claude Gingras should be contacted for questions about this dataset (gingras@lunenfeld.ca).

INSTRUMENT(S): TripleTOF 6600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Anne-Claude Gingras  

PROVIDER: MSV000090338 | MassIVE |

SECONDARY ACCESSION(S): PXD036769

REPOSITORIES: MassIVE

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Publications

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

Aprosoff Camila M CM   Dyakov Boris J A BJA   Cheung Vivian H W VHW   Wong Cassandra J CJ   Palandra Mikaela M   Gingras Anne-Claude AC   Wyatt Haley D M HDM  

Journal of proteome research 20230418 6

The DNA repair scaffold SLX4 has pivotal roles in cellular processes that maintain genome stability, most notably homologous recombination. Germline mutations in <i>SLX4</i> are associated with Fanconi anemia, a disease characterized by chromosome instability and cancer susceptibility. The role of mammalian SLX4 in homologous recombination depends critically on binding and activating structure-selective endonucleases, namely SLX1, MUS81-EME1, and XPF-ERCC1. Increasing evidence indicates that cel  ...[more]

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