Proteomics

Dataset Information

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LC-MS/MS of Versatile Decellularized Human Lung Extracellular Matrix-Derived Hydrogels


ABSTRACT: Decellularized ECM (dECM) hydrogels derived from human lungs can provide valuable insight into patient-specific and lung pathophysiology. Herein, we present the approach and some initial results that highlight the unique characteristics of this dECM hydrogel platform and its benefits for a variety of potential future studies and applications.

INSTRUMENT(S): QE+

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Weiss, Daniel J  

PROVIDER: MSV000090771 | MassIVE | Tue Nov 22 11:52:00 GMT 2022

SECONDARY ACCESSION(S): PXD038289

REPOSITORIES: MassIVE

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Publications

Regional and disease specific human lung extracellular matrix composition.

Hoffman Evan T ET   Uhl Franziska E FE   Asarian Loredana L   Deng Bin B   Becker Chloe C   Uriarte Juan J JJ   Downs Isaac I   Young Brad B   Weiss Daniel J DJ  

Biomaterials 20221224


Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), are characterized by regional extracellular matrix (ECM) remodeling which contributes to disease progression. Previous proteomic studies on whole decellularized lungs have provided detailed characterization on the impact of COPD and IPF on total lung ECM composition. However, such studies are unable to determine the differences in ECM composition between individual anatomical regi  ...[more]

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