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Supporting information for Sialic acid O-acetylation patterns and glycosidic linkage type by IM-MS

ABSTRACT: Raw ion mobility-MS data of glycans derived from biologicals, equine tissues and bovine mucin

INSTRUMENT(S): 6560 Q-TOF LC/MS

ORGANISM(S): Equus (ncbitaxon:9789) Bovinae (ncbitaxon:27592)

SUBMITTER: Geert-Jan Boons

PROVIDER: MSV000090864 | MassIVE | Wed Dec 07 23:54:00 GMT 2022

REPOSITORIES: MassIVE

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Sialic acid O-acetylation patterns and glycosidic linkage type determination by ion mobility-mass spectrometry.

Vos Gaёl M GM Hooijschuur Kevin C KC Li Zeshi Z Fjeldsted John J Klein Christian C de Vries Robert P RP Toraño Javier Sastre JS Boons Geert-Jan GJ

Nature communications 20231025 1

O-acetylation is a common modification of sialic acids that has been implicated in a multitude of biological and disease processes. A lack of analytical methods that can determine exact structures of sialic acid variants is a hurdle to determine roles of distinct O-acetylated sialosides. Here, we describe a drift tube ion mobility-mass spectrometry approach that can elucidate exact O-acetylation patterns as well as glycosidic linkage types of sialosides isolated from complex biological samples. ...[more]

PMID: 37880209

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