Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: Emre E. Turer
PROVIDER: MSV000090883 | MassIVE | Mon Dec 12 09:01:00 GMT 2022
SECONDARY ACCESSION(S): PXD038751
REPOSITORIES: MassIVE
Song Ran R McAlpine William W Fond Aaron M AM Nair-Gill Evan E Choi Jin Huk JH Nyström Elisabeth E L EEL Arike Liisa L Field Sydney S Li Xiaohong X SoRelle Jeffrey A JA Moresco James J JJ Moresco Eva Marie Y EMY Yates John R JR Azadi Parastoo P Ni Josephine J Birchenough George M H GMH Beutler Bruce B Turer Emre E EE
Nature communications 20230620 1
A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. Using a forward genetic screen, we have found a mutation in Tvp23b, which conferred susceptibility to chemically induced and infectious colitis. Trans-Golgi apparatus membrane protein TVP23 homolog B (TVP23B) is a transmembrane protein conserved from yeast to humans. We found that TVP23B controls the ...[more]