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Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

ABSTRACT: Authors: Marc P. Forrest1,2, Marc Dos Santos1,2, Nicolas H. Piguel1,2, Yi-Zhi Wang3, Nicole A. Hawkins4, Vikram A. Bagchi1,2, Leonardo E. Dionisio1,2, Sehyoun Yoon1,2, Dina Simkin3,4, Maria Dolores Martin-de-Saavedra1,2, Ruoqi Gao1,2, Katherine E. Horan1,2, Alfred L. George Jr.2,4, Mark S. LeDoux5,6, Jennifer A. Kearney 2,4, Jeffrey N. Savas2,3, Peter Penzes1,2* Affiliations: 1Department of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. 2Center for Autism and Neurodevelopment, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA 3Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. 4Department of Pharmacology Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. 5Department of Psychology, University of Memphis, Memphis, TN 38152, USA. 6Veracity Neuroscience LLC, Memphis, TN 38157, USA. *Correspondence to: p.penzes@northwestern.edu

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Jeffrey N. Savas, PhD

PROVIDER: MSV000090884 | MassIVE | Mon Dec 12 11:10:00 GMT 2022

SECONDARY ACCESSION(S): PXD038753

REPOSITORIES: MassIVE

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