Proteomics

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Rat Bronchoalveolar Lavage Proteome Changes Following E-cigarette Aerosol Exposures


ABSTRACT: Label free quantitative proteomics of bronchoalveolar lavage (BAL) fluid collected from rats exposed to e-cigarette aerosols (humidified air control, PG/VG, PG/VG + Nicotine, or PG/VG + Nicotine + Vanillin)

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116)

SUBMITTER: Wei-Jun Qian  

PROVIDER: MSV000091015 | MassIVE | Fri Jan 06 09:00:00 GMT 2023

REPOSITORIES: MassIVE

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Rat bronchoalveolar lavage proteome changes following e-cigarette aerosol exposures.

Day Nicholas J NJ   Wang Juan J   Johnston Carl J CJ   Kim So-Young SY   Olson Heather M HM   House Emma L EL   Attah Isaac Kwame IK   Clair Geremy C GC   Qian Wei-Jun WJ   McGraw Matthew D MD  

American journal of physiology. Lung cellular and molecular physiology 20230307 5


E-cigarette liquids are complex mixtures of chemicals consisting of humectants, such as propylene glycol (PG) and vegetable glycerin (VG), with nicotine or flavorings added. Published literature emphasizes the toxicity of e-cigarette aerosols with flavorings whereas much less attention has been given to the biologic effects of humectants. The purpose of the current study was to provide a comprehensive view of the acute biologic effects of e-cigarette aerosols on rat bronchoalveolar lavage (BAL)  ...[more]

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