Dataset Information

Characterisation of the gut microbiota metaproteome in patients affected by the Williams Beuren syndrome

ABSTRACT: Analyses were performed on stool samples collected from 41 patients affected by Williams Beuren syndrome (Wills, WBSs) to evaluate their gut microbiota metaproteome signatures by LFQ and LCA approaches in comparison to 45 healthy subjects (controls, CTRs, CTRLs)

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Bacteria (ncbitaxon:2) Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Valeria Marzano

PROVIDER: MSV000091045 | MassIVE | Wed Jan 11 10:01:00 GMT 2023

REPOSITORIES: MassIVE

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Publications

Williams-Beuren syndrome shapes the gut microbiota metaproteome.

Marzano Valeria V Levi Mortera Stefano S Vernocchi Pamela P Del Chierico Federica F Marangelo Chiara C Guarrasi Valerio V Gardini Simone S Dentici Maria Lisa ML Capolino Rossella R Digilio Maria Cristina MC Di Donato Maddalena M Spasari Iolanda I Abreu Maria Teresa MT Dallapiccola Bruno B Putignani Lorenza L

Scientific reports 20231103 1

Williams-Beuren syndrome (WBS) is a rare genetic neurodevelopmental disorder with multi-systemic manifestations. The evidence that most subjects with WBS face gastrointestinal (GI) comorbidities, have prompted us to carry out a metaproteomic investigation of their gut microbiota (GM) profile compared to age-matched healthy subjects (CTRLs). Metaproteomic analysis was carried out on fecal samples collected from 41 individuals with WBS, and compared with samples from 45 CTRLs. Stool were extracted ...[more]

PMID: 37923896

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