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A contractile injection system is required for developmentally regulated cell death in Streptomyces coelicolor

ABSTRACT: Diverse bacterial species produce extracellular contractile injection systems (eCISs). Although closely related to contractile phage tails, eCISs can inject toxic proteins into eukaryotic cells. Thus, these systems are commonly viewed as cytotoxic defense mechanisms that are not central to other aspects of bacterial biology. Here, we provide evidence that eCISs appear to participate in the complex developmental process of the bacterium Streptomyces coelicolor. In particular, we show that S. coelicolor produces eCIS particles during its normal growth cycle, and that strains lacking functional eCIS particles exhibit pronounced alterations in their developmental program.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Streptomyces Coelicolor A3(2) (ncbitaxon:100226)

SUBMITTER: Alan Davidson

PROVIDER: MSV000091288 | MassIVE | Wed Feb 15 14:03:00 GMT 2023

SECONDARY ACCESSION(S): PXD040128

REPOSITORIES: MassIVE

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