Proteomics

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CELA1 and AAT deficient murine model proteome

ABSTRACT: Chymotrypsin-like elastase 1 (CELA1) is a serine protease that is neutralized by alpha-1 antitrypsin (AAT) and prevents emphysema in a murine antisense oligonucleotide model of AAT-deficient emphysema. We tested the role of CELA1 in emphysema development in this genetic model of AAT-deficiency following tracheal lipopolysaccharide (LPS), 10 months of cigarette smoke (CS) exposure, aging, and a low-dose tracheal porcine pancreatic elastase (LD-PPE) model we developed. In this last model, we performed proteomic analysis to understand differences in lung protein composition. We were unable to show that AAT-deficient mice developed more emphysema than wild type with escalating doses of LPS.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Geremy Clair  

PROVIDER: MSV000091330 | MassIVE | Mon Feb 20 15:48:00 GMT 2023

REPOSITORIES: MassIVE

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Publications

Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency.

Devine Andrew J AJ   Smith Noah J NJ   Joshi Rashika R   Fan Qiang Q   Borchers Michael T MT   Clair Geremy C GC   Adkins Joshua N JN   Varisco Brian M BM  

Chronic obstructive pulmonary diseases (Miami, Fla.) 20231001 4

Chymotrypsin-like elastase 1 (CELA1) is a serine protease that is neutralized by alpha-1antitrypsin (AAT) and prevents emphysema in a murine antisense oligonucleotide model of AAT-deficient emphysema. Mice with genetic ablation of <i>AAT</i> do not have emphysema at baseline but develop emphysema with injury and aging. We tested the role of the <i>CELA1</i> gene in emphysema development in this genetic model of <i>AAT</i>-deficiency following tracheal lipopolysaccharide (LPS), 10 months of cigar  ...[more]

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