Proteomics

Dataset Information

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OOCYSTSTOP - blocking malaria transmission


ABSTRACT: The goal of OOCYSTOP is based on an innovative concept to block malaria transmission by development of new drugs that will be delivered (1) to oocysts in infected mosquitoes and (2) to early stages in human infection by the sporozoite

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Plasmodium Berghei Anka (ncbitaxon:5823)

SUBMITTER: FEDERICA FRATINI  

PROVIDER: MSV000091377 | MassIVE | Tue Feb 28 01:31:00 GMT 2023

REPOSITORIES: MassIVE

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Publications


The oocyst is a sporogonic stage of Plasmodium development that takes place in the mosquito midgut in about 2 weeks. The cyst is protected by a capsule of unknown composition, and little is known about oocyst biology. We carried out a proteomic analysis of oocyst samples isolated at early, mid, and late time points of development. Four biological replicates for each time point were analyzed, and almost 600 oocyst-specific candidates were identified. The analysis revealed that, in young oocysts,  ...[more]

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