Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Escherichia Coli (ncbitaxon:562)
SUBMITTER: Tobias Erb
PROVIDER: MSV000091532 | MassIVE | Wed Mar 22 22:46:00 GMT 2023
SECONDARY ACCESSION(S): PXD041037
REPOSITORIES: MassIVE
Nature communications 20230509 1
Formate can be envisioned at the core of a carbon-neutral bioeconomy, where it is produced from CO<sub>2</sub> by (electro-)chemical means and converted into value-added products by enzymatic cascades or engineered microbes. A key step in expanding synthetic formate assimilation is its thermodynamically challenging reduction to formaldehyde. Here, we develop a two-enzyme route in which formate is activated to formyl phosphate and subsequently reduced to formaldehyde. Exploiting the promiscuity o ...[more]