Dataset Information
The intracellular helical bundle of human glucose transporter GLUT4 is of importance for complex formation with ASPL
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Karin Lindkvist-Petersson
PROVIDER: MSV000091556 | MassIVE | Mon Mar 27 06:55:00 BST 2023
SECONDARY ACCESSION(S): PXD041130
REPOSITORIES: MassIVE
Publications
The intracellular helical bundle of human glucose transporter GLUT4 is important for complex formation with ASPL.
FEBS open bio 20230928 11
Glucose transporters (GLUTs) are responsible for transporting hexose molecules across cellular membranes. In adipocytes, insulin stimulates glucose uptake by redistributing GLUT4 to the plasma membrane. In unstimulated adipose-like mouse cell lines, GLUT4 is known to be retained intracellularly by binding to TUG protein, while upon insulin stimulation, GLUT4 dissociates from TUG. Here, we report that the TUG homolog in human, ASPL, exerts similar properties, i.e., forms a complex with GLUT4. We ...[more]
