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Melanopsin (OPN4) is a novel player in skin homeostasis and attenuates UVA-induced effects

ABSTRACT: The presence of melanopsin (OPN4) has been shown in cultured murine melanocytes and was associated with ultraviolet A radiation (UVA) reception. We demonstrated the protective role of OPN4 in skin physiology and the increased UVA-induced damage in its absence using proteomics analysis.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Ana Maria L Castrucci Jose Thalles Lacerda

PROVIDER: MSV000091592 | MassIVE | Wed Mar 29 17:30:00 BST 2023

REPOSITORIES: MassIVE

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Melanopsin (OPN4) is a novel player in skin homeostasis and attenuates UVA-induced effects.

Sua-Cespedes Cristhian C Lacerda José Thalles JT Zanetti Giovanna G David Daniela Dantas DD Moraes Maria Nathalia MN de Assis Leonardo V M LVM Castrucci Ana Maria L AML

Journal of photochemistry and photobiology. B, Biology 20230328

The presence of melanopsin (OPN4) has been shown in cultured murine melanocytes and was associated with ultraviolet A radiation (UVA) reception. Here we demonstrated the protective role of OPN4 in skin physiology and the increased UVA-induced damage in its absence. Histological analysis showed a thicker dermis and thinner hypodermal white adipose tissue layer in Opn4<sup>-/-</sup> (KO) mice than in wild-type (WT) animals. Proteomics analyses revealed molecular signatures associated with proteoly ...[more]

PMID: 37018912

Similar Datasets

Melanopsin (OPN4) is a novel player in skin homeostasis and attenuates UVA-induced effects

Project description:The presence of melanopsin (OPN4) has been shown in cultured murine melanocytes and was associated with ultraviolet A radiation (UVA) reception. We demonstrated the protective role of OPN4 in skin physiology and the increased UVA-induced damage in its absence, using proteomics analysis.

2023-03-29 | MSV000091591 | MassIVE

Melanopsin (OPN4) is a novel player in skin homeostasis and attenuates UVA-induced effects

2023-03-29 | MSV000091590 | MassIVE

Proteomics analysis of guinea pig skin in melanin deposition model

Project description:Differential expression of proteinomic changes and key signaling pathways in the skin of guinea pigs that were subjected to two distinct modeling methods that led to melanin deposition. These two modelling methods are pure ultraviolet radiation method and combined ultraviolet radiation method with progesterone.

2023-07-12 | PXD043697 |

Expression data from human skin exposed to solar-simulated radiation with or without sunscreen

2011-10-19 | GSE22083 | GEO

Melanopsin retinal ganglion cells regulate cone photoreceptor positioning in the mouse retina

Project description:We performed RNA sequencing on melanopsin deleted retinas (Opn4-DTA/DTA) to determine potential cues involved in instructing cone photoreceptor positioning

2018-05-22 | GSE112404 | GEO

How does the skin respond to genotoxic stress: The programmed gene expression change in C57BL/6 mice after ultraviolet radiation damage

Project description:Ultraviolet (UV) radiation is a major source of skin damage. It is important to define the programmed gene expression change after UV exposure, particularly in the C57BL/6 lab mice model. Here we systematically analyze the acute gene expression change in mouse skin after UV exposure.

2021-08-21 | GSE182125 | GEO

Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin

Project description:Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin

| PRJNA946651 | ENA

RNAseq of human buttock skin from healthy controls exposed to solar simulated radiation

Project description:The aim of this study was to investigate cutaneous cellular and molecular events in the photodermatoses (including solar urticaria and photoaggravated atopic dermatitis) following solar simulated ultraviolet radiation (SSR) exposure, and this dataset comprised the healthy controls (HC). Cutaneous biopsies were taken from unexposed skin and from skin exposed to a single low (physiological) dose of SSR, at 30 minutes, 3 hours, 24 hours and 72 hours post-exposure, in n=6 HC. Biopsies were assessed by immunohistochemistry (n=6 HC) and RNA-sequencing analysis (n=4 HC).

2024-03-18 | E-MTAB-12218 | biostudies-arrayexpress

Expression data from human skin exposed to solar-simulated radiation with or without sunscreen

Project description:Despite widespread use of sunscreens that minimize erythema by blocking ultraviolet B (UVB) radiation, incidence rates of melanoma continue to rise. In considering this disparity between intervention and disease prevalence, we investigated the in vivo transcriptome of human skin treated with sunscreen and solar-simulated radiation (ssR). A focal skin area of healthy participants was exposed to ssR at 1 minimal erythema dose (MED), 0.1 MED or 100 J/m2 with or without prior application of sunscreen, or to non-UVB-spectrum of ssR (solar-simulated UVA/visible/infrared radiation: ssA). Skin biopsies were analyzed using expression microarrays. Ninety-eight microarrays from 14 healthy human volunteers were analyzed. Focal skin areas of all 14 volunteers were exposed to 0 J/m2, 100 J/m2, 1 minimal erythema dose (MED), and 0.1 MED of solar-simulated radiation (ssR). Eight of the 14 volunteers (Group 1) were also exposed to ssA (ssR minus UVB) that were generated by removing UVB from 0 J/m2, 100 J/m2, 1 minimal erythema dose (MED), and 0.1 MED of ssR. Additionally, 6 of the 14 volunteers (Group 2) were treated with sunscreen of sun protection factor (SPF) 15, and exposed to 0 J/m2, 100 J/m2, 1 minimal erythema dose (MED), and 0.1 MED of ssR. Biopsy was taken 24 hours after exposure from each focal skin area for RNA extraction.

2011-10-18 | E-GEOD-22083 | biostudies-arrayexpress

Differential Expression Profiles and Function Predictions for tRFs & tiRNAs in Skin Injury Induced by Ultraviolet Irradiation

Project description:Purpose: to explore the function and mechanism of skin damage induced by ultraviolet irradiation. Method: Skin tRF & tiRNA profiles of mice normal skin and damage skin induced by Ultraviolet Irradiation (UV) were generated by deep sequencing, using Illumina NextSeq 500. qRT–PCR validation was performed using SYBR Green assays. Results:Sequencing was used to screen expression profiles and predict target genes. Compared with normal skin, a total of 31 differentially expressed tRFs and tiRNAs were screened. Among these, 10 tRFs and tiRNAs were shown to be significantly different in expression levels, where there were 4 up-regulated and 6 down-regulated target genes.Altered expression of 4 genes was confirmed with qRT–PCR, demonstrating the high degree of sensitivity of the RNA-seq method. Hierarchical clustering of differentially expressed genes uncovered several as yet uncharacterized genes that may contribute to skin repair after damage induced by ultraviolet irradiation. Conclusion: tRF-Trp-TCA-001 and tRF-Gly-CCC-019 plays an important role in acute skin injury induced by UVB radiation by regulating the ras-related C3 botulinum toxin substrate 1 (Rac1) gene in the WNT signaling pathway. This study provides new insights into the mechanisms and therapeutic targets of UV-induced skin injury.

2021-08-06 | GSE162641 | GEO

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