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12_pharmacometabolomics_depression_DF

ABSTRACT: We carried out untargeted metabolomics of the prefrontal cortex of rats exposed to chronic social isolation (CSIS), a rat model of depression, and/or fluoxetine treatment using liquid chromatography-high resolution mass spectrometry.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116)

SUBMITTER: Dragana Filipovic Julica Inderhees

PROVIDER: MSV000092101 | MassIVE | Mon Jun 05 08:17:00 BST 2023

REPOSITORIES: MassIVE

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Publications

Metabolic Fingerprints of Effective Fluoxetine Treatment in the Prefrontal Cortex of Chronically Socially Isolated Rats: Marker Candidates and Predictive Metabolites.

Filipović Dragana D Inderhees Julica J Korda Alexandra A Tadić Predrag P Schwaninger Markus M Inta Dragoš D Borgwardt Stefan S

International journal of molecular sciences 20230630 13

The increasing prevalence of depression requires more effective therapy and the understanding of antidepressants' mode of action. We carried out untargeted metabolomics of the prefrontal cortex of rats exposed to chronic social isolation (CSIS), a rat model of depression, and/or fluoxetine treatment using liquid chromatography-high resolution mass spectrometry. The behavioral phenotype was assessed by the forced swim test. To analyze the metabolomics data, we employed univariate and multivariate ...[more]

PMID: 37446133

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