Dataset Information

Effects of the chlorophyll derivative 132-hydroxypheophytine a on zebrafish metabolomics

ABSTRACT: Zebrafish larvae were exposed from 3 DPF to 5 DPF to the chlorophyll derivative 13-2-hydroxypheophytine a. Metabolites were extracted with some modification of the protocol published by Lin et al 2019 (10.1016/j.bbrc.2019.04.003.). 3 experimental groups: DMSO 0.1% (solvent control) and hpa at 7.5 ug/ml (hpa1) and at 15 ug/ml (hpa2). All details can be found in the paper that published this data set. Title: Insights into the mechanism of action of the chlorophyll derivative 132-hydroxypheophytine a on reducing neutral lipid reserves in zebrafish larvae and mice adipocytes Authors: Ana Carrasco del Amor, Rene Hernandez Butista, Siegfried Ussar, Susana Cristobal, Ralph Urbatzka European Journal of Pharmacology accepted: 10/24/2023 doi: 10.1016/j.ejphar.2023.176158

INSTRUMENT(S): Orbitrap Exploris 120

ORGANISM(S): Danio Rerio (ncbitaxon:7955)

SUBMITTER: Ralph Urbatzka

PROVIDER: MSV000092187 | MassIVE | Fri Jun 16 04:18:00 BST 2023

REPOSITORIES: MassIVE

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Insights into the mechanism of action of the chlorophyll derivative 13-<sup>2</sup>-hydroxypheophytine a on reducing neutral lipid reserves in zebrafish larvae and mice adipocytes.

Carrasco Del Amor Ana A Bautista Rene Hernandez RH Ussar Siegfried S Cristobal Susana S Urbatzka Ralph R

European journal of pharmacology 20231026

Obesity is a worldwide epidemic and natural products may hold promise in its treatment. The chlorophyll derivative 13-<sup>2</sup>-hydroxypheophytine (hpa) was isolated in a screen with zebrafish larvae to identify lipid reducing molecules from cyanobacteria. However, the mechanisms underlying the lipid-reducing effects of hpa in zebrafish larvae remain poorly understood. Thus, investigating the mechanism of action of hpa and validation in other model organisms such as mice represents important ...[more]

PMID: 37898286

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