Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Inflammatory bowel disease fecal samples

ABSTRACT: LC-MS files used for quantitation of bile acids in fecal samples.

INSTRUMENT(S): maXis

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Pieter C. Dorrestein

PROVIDER: MSV000092337 | MassIVE | Mon Jul 03 15:45:00 BST 2023

REPOSITORIES: MassIVE

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

GNPS_Inflammatory bowel disease fecal samples

Project description:LC-MS files used for quantitation of bile acids in fecal samples.

2023-07-03 | MSV000092337 | GNPS

Fecal metabolites identify liver transplant recipients at risk for peri-operative infection

Project description:Targeted metabolomics performed by GC-MS (for SCFAs by PFBBr derivatization) and LC-MS (for bile acids) on fecal samples from liver transplant patients.

2023-11-09 | MSV000093347 | MassIVE

Metaproteomics of fecal samples supports the diagnosis of Crohn’s Disease and Ulcerative Colitis

Project description:Objective Crohn’s Disease (CD) and Ulcerative Colitis (UC) are chronic inflammatory diseases of the gastrointestinal tract. Reliable diagnosis of these diseases requires a comprehensive examination of the patient, which include invasive endoscopy. This study assesses whether non-invasive LC-MS/MS based analysis of microbial and human proteins from feces may support the diagnosis of the diseases. Design In order to mimic a representative clinical background for this study, we investigated 17 healthy controls, 11 CD patients, 14 UC patients, also 13 Irritable Bowel Disease (IBS) patients, 8 Colon Adenoma (CA) patients, and 8 Gastric Carcinoma (GCA) patients. The proteins were extracted from the fecal samples with liquid phenol in a ball mill. Subsequently, the proteins were digested tryptically to peptides and analyzed by liquid chromatography coupled to an Orbitrap MS/MS. For protein identification and interpretation of taxonomic and functional results, the MetaProteomeAnalyzer software and the UniProtKB/SwissProt database and several metagenomes from human fecal samples were used. Results Cluster analysis and ANOSIM show a separation of healthy controls from patients with CD and UC as well as from patients with GCA. Among others, UC and CD correlated with an increase of neutrophil extracellular traps and immunoglobulins G (IgG) as well as a decrease of IgA. A specific marker metaprotein for CD was an increase of the human enzyme sucrose-isomaltase. IBS and CA patient’s fecal metaproteome showed only minor alterations. Conclusion Metaproteome analysis distinguished between patients with UC, CD and healthy controls and is therefore useful as a non-invasive tool for routine diagnostics in hospitals.

2019-03-11 | PXD010371 | Pride

Fecal samples

Project description:Fecal samples Metagenome

| PRJNA730197 | ENA

Quantitative analysis of bile acids in fecal samples from centenarians, elderly and young subjects.

Project description:Fecal samples from centenarians (>100 yo), elderly (85-89 yo) and young (21-55) subjects were analysed using LC-MS/MS. 48 bile acids were measured by targeted metabolomics.

2021-05-24 | ST001851 | MetabolomicsWorkbench

Fecal samples

Project description:TD Fecal samples Metagenome

| PRJNA633337 | ENA

DDW fecal samples

Project description:Metabolite analysis of DDW fecal samples, standard methanol extraction. Data were acquired using a Bruker Daltonics maXis Impact and C18 RP-UHPLC. Positive polarity acquisition of LC-MS/MS.

2018-05-09 | MSV000082354 | MassIVE

fecal samples

Project description:fecal samples Raw sequence reads

| PRJNA827995 | ENA

Fecal samples

Project description:Fecal samples Raw sequence reads

| PRJNA420628 | ENA

Fecal samples

Project description:Fecal samples Raw sequence reads

| PRJNA507462 | ENA