Proteomics

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Proteomic changes in mouse brain expressing WT and mutant (S3) alleles of the prion protein

ABSTRACT: Label-free quantification of proteomic changes in mouse expressing WT, mutant (S3) prion protein, and PrP-KO mouse. Three biological replicates were included per condition. In-gel digestion of the proteins extracted from brain generated 6 fractions per replicate.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Olivier Julien  

PROVIDER: MSV000092545 | MassIVE | Thu Jul 27 13:29:00 BST 2023

REPOSITORIES: MassIVE

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Publications

Application of N-Terminal Labeling Methods Provide Novel Insights into Endoproteolysis of the Prion Protein <i>in Vivo</i>.

Gomez-Cardona Erik E   Eskandari-Sedighi Ghazaleh G   Fahlman Richard R   Westaway David D   Julien Olivier O  

ACS chemical neuroscience 20231214 1

Alternative α- and β-cleavage events in the cellular prion protein (PrP<sup>C</sup>) central region generate fragments with distinct biochemical features that affect prion disease pathogenesis, but the assignment of precise cleavage positions has proven challenging. Exploiting mouse transgenic models expressing wild-type (WT) PrP<sup>C</sup> and an octarepeat region mutant allele (S3) with increased β-fragmentation, cleavage sites were defined using LC-MS/MS in conjunction with N-terminal enzyma  ...[more]

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