Using FAIMS to improve tumor neoantigen detection
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Robert Schreiber Cheryl Lichti
PROVIDER: MSV000092617 | MassIVE | Tue Aug 08 07:33:00 BST 2023
SECONDARY ACCESSION(S): PXD044450
REPOSITORIES: MassIVE
Publications
Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry.
Meng Wei W Takeuchi Yoshiko Y Ward Jeffrey P JP Sultan Hussein H Arthur Cora D CD Mardis Elaine R ER Artyomov Maxim N MN Lichti Cheryl F CF Schreiber Robert D RD
Cancer immunology research 20240801 8
Cancer neoantigens have been shown to elicit cancer-specific T-cell responses and have garnered much attention for their roles in both spontaneous and therapeutically induced antitumor responses. Mass spectrometry (MS) profiling of tumor immunopeptidomes has been used, in part, to identify MHC-bound mutant neoantigen ligands. However, under standard conditions, MS-based detection of such rare but clinically relevant neoantigens is relatively insensitive, requiring 300 million cells or more. Here ...[more]
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