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Molecular Basis of Oligopeptide Recognition and Transport in the Pneumococcal Ami permease system

ABSTRACT: dataset to create a peptide candidate list of E. coli peptides bound to either AliB or AmiA from Streptococcus pneumoniae.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Escherichia Coli Bl21 (ncbitaxon:511693)

SUBMITTER: Dr. Leif Steil

PROVIDER: MSV000092727 | MassIVE | Wed Aug 23 02:44:00 BST 2023

REPOSITORIES: MassIVE

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Molecular and structural basis of oligopeptide recognition by the Ami transporter system in pneumococci.

Alcorlo Martín M Abdullah Mohammed R MR Steil Leif L Sotomayor Francisco F López-de Oro Laura L de Castro Sonia S Velázquez Sonsoles S Kohler Thomas P TP Jiménez Elisabet E Medina Ana A Usón Isabel I Keller Lance E LE Bradshaw Jessica L JL McDaniel Larry S LS Camarasa María-José MJ Völker Uwe U Hammerschmidt Sven S Hermoso Juan A JA

PLoS pathogens 20240605 6

ATP-binding cassette (ABC) transport systems are crucial for bacteria to ensure sufficient uptake of nutrients that are not produced de novo or improve the energy balance. The cell surface of the pathobiont Streptococcus pneumoniae (pneumococcus) is decorated with a substantial array of ABC transporters, critically influencing nasopharyngeal colonization and invasive infections. Given the auxotrophic nature of pneumococci for certain amino acids, the Ami ABC transporter system, orchestrating oli ...[more]

PMID: 38838057

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