Proteomics

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Disruption of KLHL6 Dimerization Fuels Oncogenic Antigen Receptor Signaling in B-cell Lymphoma


ABSTRACT: In malignant B-cell context, application of affinity-purification mass spectrometry (AP-MS) on KLHL6 baits revealed novel physical protein interaction partners outside the established ubiquitination/protein degradation machinery, such as BCR signaling components CD79A and Bank1. As a complementary approach to AP-MS, Kelch-domain adjacent proximity-dependent labeling (BioID2) revealed potential substrates processed by the identified KLHL6-CRLs.

INSTRUMENT(S): Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Markku Varjosalo  

PROVIDER: MSV000092728 | MassIVE | Wed Aug 23 03:13:00 BST 2023

REPOSITORIES: MassIVE

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