Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Wei-Jun Qian
PROVIDER: MSV000093136 | MassIVE | Tue Oct 17 20:53:00 BST 2023
SECONDARY ACCESSION(S): PXD046200
REPOSITORIES: MassIVE
Day Nicholas J NJ Kelly Shane S SS Lui Li-Yung LY Mansfield Tyler A TA Gaffrey Matthew J MJ Trejo Jesse B JB Sagendorf Tyler J TJ Attah Isaac K IK Moore Ronald J RJ Douglas Collin M CM Newman Anne B AB Kritchevsky Stephen B SB Kramer Philip A PA Marcinek David J DJ Coen Paul M PM Goodpaster Bret H BH Hepple Russell T RT Cawthon Peggy M PM Petyuk Vladislav A VA Esser Karyn A KA Qian Wei-Jun WJ Cummings Steven R SR
Aging cell 20240208 6
Oxidative stress is considered a contributor to declining muscle function and mobility during aging; however, the underlying molecular mechanisms remain poorly described. We hypothesized that greater levels of cysteine (Cys) oxidation on muscle proteins are associated with decreased measures of mobility. Herein, we applied a novel redox proteomics approach to measure reversible protein Cys oxidation in vastus lateralis muscle biopsies collected from 56 subjects in the Study of Muscle, Mobility a ...[more]