Proteomics

Dataset Information

0

Signatures of Cysteine Oxidation on Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults


ABSTRACT: Human muscle biopsies from older adults were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Wei-Jun Qian  

PROVIDER: MSV000093136 | MassIVE | Tue Oct 17 20:53:00 BST 2023

SECONDARY ACCESSION(S): PXD046200

REPOSITORIES: MassIVE

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1
altmetric image

Publications


Oxidative stress is considered a contributor to declining muscle function and mobility during aging; however, the underlying molecular mechanisms remain poorly described. We hypothesized that greater levels of cysteine (Cys) oxidation on muscle proteins are associated with decreased measures of mobility. Herein, we applied a novel redox proteomics approach to measure reversible protein Cys oxidation in vastus lateralis muscle biopsies collected from 56 subjects in the Study of Muscle, Mobility a  ...[more]

Publication: 1/2

Similar Datasets

2003-04-03 | GSE362 | GEO
| S-EPMC10659491 | biostudies-literature
2018-07-24 | GSE117525 | GEO
2018-11-30 | GSE120642 | GEO
2019-06-10 | GSE123993 | GEO
2007-07-16 | GSE8479 | GEO
2024-10-22 | PXD056507 | Pride
2020-09-08 | GSE157585 | GEO
2007-12-13 | E-GEOD-362 | biostudies-arrayexpress
2020-12-06 | GSE162730 | GEO