Identification of non-conventional small molecule degraders and stabilizers of squalene synthase
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ABSTRACT: The dataset was obtained by performing a TMTpro16plex expression proteomics experiment, where HeLa cells were treated with small molecule ligands of squalene synthase (FDFT1). The experiment was successful in re-producing previously obtained Western Blot results in regards to SQS (=FDFT1) levels and aimed at elucidating downstream effects on cholesterol biosynthesis and metabolism. The dataset comprises data for the following samples: DMSO (vehicle), KY02111, PROTAC 18, SQSI and a compound unrelated to this project (TMTpro16plex, processed by Maxquant, each collected in 30 fractions). The experiments were performed in three independent replicates for each compound (R1-R3).
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Luca laraia
PROVIDER: MSV000093137 | MassIVE | Wed Oct 18 01:04:00 BST 2023
REPOSITORIES: MassIVE
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