Egg MVBs elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization
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ABSTRACT: Abstract:
Mitochondria are maternally inherited, but the mechanisms underlying paternal mitochondrial elimination (PME) after fertilization are far less clear. In Drosophila, special egg-derived multivesicular bodies (MVBs) promote PME. To uncover the cellular degradative pathway mediated by the MVBs to degrade the sperm mitochondrial derivative, we isolated these vesicles from early fertilized eggs, using a subcellular fractionation procedure and subjected them to mass spectrometry (MS) analysis.
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227)
SUBMITTER: Eli Arama
PROVIDER: MSV000093306 | MassIVE | Mon Nov 06 02:35:00 GMT 2023
SECONDARY ACCESSION(S): PXD046694
REPOSITORIES: MassIVE
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