Proteomics

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Egg MVBs elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization


ABSTRACT: Abstract: Mitochondria are maternally inherited, but the mechanisms underlying paternal mitochondrial elimination (PME) after fertilization are far less clear. In Drosophila, special egg-derived multivesicular bodies (MVBs) promote PME. To uncover the cellular degradative pathway mediated by the MVBs to degrade the sperm mitochondrial derivative, we isolated these vesicles from early fertilized eggs, using a subcellular fractionation procedure and subjected them to mass spectrometry (MS) analysis.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227)

SUBMITTER: Eli Arama  

PROVIDER: MSV000093306 | MassIVE | Mon Nov 06 02:35:00 GMT 2023

SECONDARY ACCESSION(S): PXD046694

REPOSITORIES: MassIVE

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