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Proteome changes in larval zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) exposed anatoxin-a fumerate.

ABSTRACT: Characterization of proteome changes to zebrafish and fathead minnow following exposure to the Anatoxin-a surrogate anatoxin-fumerate.

INSTRUMENT(S): Synapt G2 MS

ORGANISM(S): Pimephales Promelas (ncbitaxon:90988) Danio Rerio (ncbitaxon:7955)

SUBMITTER: Laura Langan

PROVIDER: MSV000093536 | MassIVE | Wed Nov 29 10:23:00 GMT 2023

REPOSITORIES: MassIVE

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Proteome changes in larval zebrafish (Danio rerio) and fathead minnow (Pimephales promelas) exposed to (±) anatoxin-a.

Langan Laura M LM Lovin Lea M LM Taylor Raegyn B RB Scarlett Kendall R KR Kevin Chambliss C C Chatterjee Saurabh S Scott J Thad JT Brooks Bryan W BW

Environment international 20240218

Anatoxin-a and its analogues are potent neurotoxins produced by several genera of cyanobacteria. Due in part to its high toxicity and potential presence in drinking water, these toxins pose threats to public health, companion animals and the environment. It primarily exerts toxicity as a cholinergic agonist, with high affinity at neuromuscular junctions, but molecular mechanisms by which it elicits toxicological responses are not fully understood. To advance understanding of this cyanobacteria, ...[more]

PMID: 38394915

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