Proteomics

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5HT - Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3


ABSTRACT: we provide evidence for a new class of histone posttranslational modification (PTM): serotonylation.

INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Ian Maze  

PROVIDER: MSV000093567 | MassIVE | Mon Dec 04 15:54:00 GMT 2023

SECONDARY ACCESSION(S): PXD008106

REPOSITORIES: MassIVE

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Publications


Chemical modifications of histones can mediate diverse DNA-templated processes, including gene transcription<sup>1-3</sup>. Here we provide evidence for a class of histone post-translational modification, serotonylation of glutamine, which occurs at position 5 (Q5ser) on histone H3 in organisms that produce serotonin (also known as 5-hydroxytryptamine (5-HT)). We demonstrate that tissue transglutaminase 2 can serotonylate histone H3 tri-methylated lysine 4 (H3K4me3)-marked nucleosomes, resulting  ...[more]

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