Proteomics

Dataset Information

0

Heart proteomics of pathological atrial enlargement associated with atrial fibrillation


ABSTRACT: Atrial fibrillation (AF) remains challenging to prevent and treat. It is associated with increased rates of heart failure, stroke and neurological decline. A key feature of AF is atrial enlargement. However, not all atrial enlargement progresses to pathology and AF. In the current study, we characterized mouse atria from a 1) pathological model (cardiac-specific transgenic (Tg) that develops dilated cardiomyopathy [DCM] and AF due to reduced protective signalling [PI3K]; DCM-dnPI3K), and a 2) physiological model (cardiac-specific Tg with an enlarged heart due to increased insulin-like growth factor 1 receptor; IGF1R). Atrial enlargement in the DCM-dnPI3K Tg, but not IGF1R Tg, was associated with atrial dysfunction, fibrosis and a heart failure gene expression pattern. Proteomics analysis identified proteins and pathways that were differentially regulated in pathological and physiological atrial enlargement, and provides a resource to study potential drug targets for AF.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: David Greening  

PROVIDER: MSV000093605 | MassIVE | Thu Dec 07 19:24:00 GMT 2023

SECONDARY ACCESSION(S): PXD047631

REPOSITORIES: MassIVE

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-04-06 | GSE129409 | GEO
2019-01-01 | GSE123823 | GEO
2024-02-08 | GSE225293 | GEO
2014-10-28 | E-GEOD-62727 | biostudies-arrayexpress
2017-04-25 | GSE68475 | GEO
2023-06-30 | GSE229525 | GEO
2018-04-12 | GSE113013 | GEO
2014-10-28 | GSE62727 | GEO
2019-08-29 | GSE106201 | GEO
2019-12-13 | GSE128908 | GEO