Heart proteomics of pathological atrial enlargement associated with atrial fibrillation
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ABSTRACT: Atrial fibrillation (AF) remains challenging to prevent and treat. It is associated with increased rates of heart failure, stroke and neurological decline. A key feature of AF is atrial enlargement. However, not all atrial enlargement progresses to pathology and AF.
In the current study, we characterized mouse atria from a 1) pathological model (cardiac-specific transgenic (Tg) that develops dilated cardiomyopathy [DCM] and AF due to reduced protective signalling [PI3K]; DCM-dnPI3K), and a 2) physiological model (cardiac-specific Tg with an enlarged heart due to increased insulin-like growth factor 1 receptor; IGF1R). Atrial enlargement in the DCM-dnPI3K Tg, but not IGF1R Tg, was associated with atrial dysfunction, fibrosis and a heart failure gene expression pattern. Proteomics analysis identified proteins and pathways that were differentially regulated in pathological and physiological atrial enlargement, and provides a resource to study potential drug targets for AF.
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: David Greening
PROVIDER: MSV000093605 | MassIVE | Thu Dec 07 19:24:00 GMT 2023
SECONDARY ACCESSION(S): PXD047631
REPOSITORIES: MassIVE
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