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Chemogenetic restoration of astrocyte morphology is beneficial in obsessive-compulsive disorder

ABSTRACT: In vivo chemogenetic activation of astrocytes in the striatum via an engineered Gi-protein-coupled receptor was conducted in wild-type and SAPAP3 KO OCD mice. The resultant striatal tissue was extracted, homogenized in a detergent-free buffer, digested, and analyzed with LC/MS-MS.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Baljit Khakh

PROVIDER: MSV000093698 | MassIVE | Tue Dec 19 14:02:00 GMT 2023

REPOSITORIES: MassIVE

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