Dataset Information

UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER

ABSTRACT: Supporting MS data for paper (doi: 10.1038/s41586-024-07073-0) by DaRosa P.A., Penchev I. et al., titled "UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER". Index of MS supporting files uploaded: Related to Related to Fig. 1b, c (xb01004(UFM1), xb01005(SBP-UFM1): LFQ IP-MS (Unimod: 35; 4)). See also MSV000093510

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Alban Ordureau

PROVIDER: MSV000093721 | MassIVE | Fri Dec 22 08:53:00 GMT 2023

REPOSITORIES: MassIVE

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UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.

DaRosa Paul A PA Penchev Ivan I Gumbin Samantha C SC Scavone Francesco F Wąchalska Magda M Paulo Joao A JA Ordureau Alban A Peter Joshua J JJ Kulathu Yogesh Y Harper J Wade JW Becker Thomas T Beckmann Roland R Kopito Ron R RR

Nature 20240221 8003

Reversible modification of target proteins by ubiquitin and ubiquitin-like proteins (UBLs) is widely used by eukaryotic cells to control protein fate and cell behaviour<sup>1</sup>. UFM1 is a UBL that predominantly modifies a single lysine residue on a single ribosomal protein, uL24 (also called RPL26), on ribosomes at the cytoplasmic surface of the endoplasmic reticulum (ER)<sup>2,3</sup>. UFM1 conjugation (UFMylation) facilitates the rescue of 60S ribosomal subunits (60S) that are released aft ...[more]

PMID: 38383785

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