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Oxidative Cyclization Reagents Reveal Tryptophan Cation-pi interactions

ABSTRACT: Raw data of the project "Oxidative Cyclization Reagents Reveal Tryptophan Cation-pi interactions"

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Christopher J. Chang

PROVIDER: MSV000093891 | MassIVE | Thu Jan 18 23:03:00 GMT 2024

REPOSITORIES: MassIVE

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Publications

Oxidative cyclization reagents reveal tryptophan cation-π interactions.

Xie Xiao X Moon Patrick J PJ Crossley Steven W M SWM Bischoff Amanda J AJ He Dan D Li Gen G Dao Nam N Gonzalez-Valero Angel A Reeves Audrey G AG McKenna Jeffrey M JM Elledge Susanna K SK Wells James A JA Toste F Dean FD Chang Christopher J CJ

Nature 20240306 8004

Methods for selective covalent modification of amino acids on proteins can enable a diverse array of applications, spanning probes and modulators of protein function to proteomics<sup>1-3</sup>. Owing to their high nucleophilicity, cysteine and lysine residues are the most common points of attachment for protein bioconjugation chemistry through acid-base reactivity<sup>3,4</sup>. Here we report a redox-based strategy for bioconjugation of tryptophan, the rarest amino acid, using oxaziridine reag ...[more]

PMID: 38448587

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