Proteomics

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Serum proteome in metastatic breast cancer patients


ABSTRACT: We identified 967 proteins among 75 serum samples from patients with BC. Among these, 39 proteins were altered in serum samples at diagnosis, between progressors and non-progressors. Among these, 4 proteins were further altered when the progressors developed distant metastasis. In addition, within progressors, 20 proteins were altered in serum collected at diagnosis versus at the onset of metastasis. Pathway analysis showed that these proteins encoded pathways that describe metastasis, including epithelial mesenchymal transition and focal adhesion that are hallmarks of metastatic cascade.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Sung Yun Jung  

PROVIDER: MSV000094255 | MassIVE | Thu Mar 07 09:28:00 GMT 2024

SECONDARY ACCESSION(S): PXD050451

REPOSITORIES: MassIVE

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Publications

Quantitative proteomics reveals serum proteome alterations during metastatic disease progression in breast cancer patients.

Kaur Jaspreet J   Jung Sung Yun SY   Austdal Marie M   Arun Aaditya Krishna AK   Helland Thomas T   Mellgren Gunnar G   Lende Tone Hoel TH   Janssen Emiel A M EAM   Søiland Håvard H   Aneja Ritu R  

Clinical proteomics 20240729 1


<h4>Background</h4>Tumor recurrence and metastatic progression remains the leading cause for breast cancer related mortalities. However, the proteomes of patient- matched primary breast cancer (BC) and metastatic lesions have not yet been identified, due to the lack of clinically annotated longitudinal samples. In this study, we evaluated the global-proteomic landscape of BC patients with and without distant metastasis as well as compared the proteome of distant metastatic disease with its corre  ...[more]

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