Proteomics

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Proteomic profile of hippocampus regions from the pilocarpine medial temporal lobe epilepsy model

ABSTRACT: Label-free Proteomic profile of the dentate gyrus (dorsal and ventral) and CA3 (dorsal and ventral) microdissected from the hippocampus of the pilocarpine model of Mesial Temporal Lobe Epilepsy.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116)

SUBMITTER: Iscia Lopes Cendes  

PROVIDER: MSV000094401 | MassIVE | Mon Mar 25 10:59:00 GMT 2024

SECONDARY ACCESSION(S): PXD050962

REPOSITORIES: MassIVE

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Mesial temporal lobe epilepsy (MTLE) is a chronic neurological disorder characterized by the occurrence of seizures, and histopathological abnormalities in the mesial temporal lobe structures, mainly hippocampal sclerosis (HS). We used a multi-omics approach to determine the profile of transcript and protein expression in the dorsal and ventral hippocampal dentate gyrus (DG) and Cornu Ammonis 3 (CA3) in an animal model of MTLE induced by pilocarpine. We performed label-free proteomics and RNAseq  ...[more]

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