Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Streptomyces Albidoflavus J1074 Streptomyces Coelicolor M1146
SUBMITTER: Andrew Truman
PROVIDER: MSV000094563 | MassIVE | Thu Apr 18 07:37:00 BST 2024
REPOSITORIES: MassIVE
Nature chemical biology 20240916
The main biopolymers in nature are oligonucleotides and polypeptides. However, naturally occurring peptide-nucleobase hybrids are rare. Here we report the characterization of the founding member of a class of peptide-nucleobase hybrid natural products with a pyrimidone motif from a widely distributed ribosomally synthesized and post-translationally modified (RiPP) biosynthetic pathway. This pathway features two steps where a heteromeric RRE-YcaO-dehydrogenase complex catalyzes the formation of a ...[more]