Proteomics

Dataset Information

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Streptamidine, streptapyrimidone and spyrimidone production in Streptomyces albidoflavus J1074 and S. coelicolor M1146-pCAPSalbC


ABSTRACT: Data used to evaluate temporal progression of streptamidine, streptapyrimidone, spyrimidone and glycosylated spyrimidone production in Streptomyces albidoflavus J1074 and the heterologous host Streptomyces coelicolor M1146 expressing the streptamidine (ami) cluster. LC-MS/MS data used to characterise spyrimidone (199Da) and streptapyrimidone (827Da).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Streptomyces Albidoflavus J1074 Streptomyces Coelicolor M1146

SUBMITTER: Andrew Truman  

PROVIDER: MSV000094563 | MassIVE | Thu Apr 18 07:37:00 BST 2024

REPOSITORIES: MassIVE

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Publications

Biosynthesis of peptide-nucleobase hybrids in ribosomal peptides.

Pei Zeng-Fei ZF   Vior Natalia M NM   Zhu Lingyang L   Truman Andrew W AW   Nair Satish K SK  

Nature chemical biology 20240916


The main biopolymers in nature are oligonucleotides and polypeptides. However, naturally occurring peptide-nucleobase hybrids are rare. Here we report the characterization of the founding member of a class of peptide-nucleobase hybrid natural products with a pyrimidone motif from a widely distributed ribosomally synthesized and post-translationally modified (RiPP) biosynthetic pathway. This pathway features two steps where a heteromeric RRE-YcaO-dehydrogenase complex catalyzes the formation of a  ...[more]

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