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Molecular mechanism of Contactin 2 homophilic interaction

ABSTRACT: Contactin 2 (CNTN2), a neuronal guidance molecule, forms transient homodimers. Cryo-electron microscopy reveals that the CNTN2 homodimer forms a T-shaped particle composed of parallel, intertwined monomers. A central homodimeric stalk places headpieces, leveraged by CNTNs to bind heterophilic partners, on either side, indicating that homophilic and heterophilic binding mechanisms are distinct.

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: William Russell

PROVIDER: MSV000094883 | MassIVE | Tue May 28 12:33:00 BST 2024

REPOSITORIES: MassIVE

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