DIA-SWATH analysis of the effect of cysteamine in cystinotic fibroblasts
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ABSTRACT: Fibroblast cell lines form cystinotic and non-cystinotic fibroblast were incubated for 48h with increasing amounts of cysteamine, the only available treatment for cystinosis, an incurable metabolic rare disease that is characterized by accumulation of cystine crystals in the cells and accompanied by detrimental symptoms at the renal, ocular, and muscular levels. Cysteamine treatment delays the symptoms and improves the quality of life of the patients, but the patients depend on it for life. Furthermore, oral cysteamine treatment present undesirable side effects and fails in avoiding the end-stage renal failure that inevitably drives to kidney transplant. Our results will be helpful to understand, from a molecular point of view, the benefits, deficiencies, and detrimental effects of the cysteamine treatment.
INSTRUMENT(S): ZenoTOF 7600
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Jesus Mateos
PROVIDER: MSV000095020 | MassIVE | Thu Jun 13 05:51:00 BST 2024
REPOSITORIES: MassIVE
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