Dataset Information
Thermal Proteome Profiling Analysis of Targets of NSC59984 in ESO26-R248W Cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
Lisa Jenkins
PROVIDER: MSV000095372 | MassIVE | Thu Jul 18 07:21:00 BST 2024
REPOSITORIES: MassIVE
Publications
Covalent Modification of p53 by (<i>E</i>)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one.
ACS pharmacology & translational science 20241014 11
<i>TP53</i> is commonly mutated in cancer, giving rise to loss of wild-type tumor suppressor function and increases in gain-of-function oncogenic roles. Thus, inhibition of mutant p53 and reactivation of wild-type function represents a potential means to target diverse tumor types. (<i>E</i>)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one (NSC59984), first identified from a high-throughput screen, induces wild-type p53 signaling and antiproliferative effects while inhibiting mut ...[more]
