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Effects of light exposure on circulating metabolites in mice

ABSTRACT: The goal of this project is to identify metabolites released from subcutaneous adipose tissue due to light exposure that regulate systemic metabolism. We found that histidine levels increased by 8 days of blue light exposure, both in the treated subcutaneous adipose tissue and in circulation. Additionally, blue light-induced circulating histidine levels were not affected by the central blockade of histidine decarboxylase activity using FMH (Fluoromethylhistidine) in the hypothalamus. The details are described in the Summary Excel file.

INSTRUMENT(S): RP_Shimadzu Nexera UPLC and Sciex TripleTOF 6600, GCMS_Agilent 7980B Gas Chromatograph and Pegasus HT TOF MS, TQ_Shimadzu Nexera UPLC and Sciex 5500 Triple Quadrupole MS

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Yu-Hua Tseng

PROVIDER: MSV000095379 | MassIVE | Thu Jul 18 15:35:00 BST 2024

SECONDARY ACCESSION(S): PXD054050

REPOSITORIES: MassIVE

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