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Pilot Study on Differential Urine Proteomic Profile of Subjects with Community Acquired Acute Kidney Injury Who Recover Versus Those Who Do Not Recover Completely at 4 months after Hospital Discharge

ABSTRACT: Community acquired acute kidney injury (CAAKI) is a sudden structural damage and loss of kidney function in otherwise healthy individuals outside of hospital settings having high morbidity and mortality rates worldwide. Long-term sequelae of AKI involve an associated risk of progression to chronic kidney disease (CKD). Serum creatinine (SCr) the currently used clinical parameter for diagnosing AKI varies greatly with age, gender, diet and muscle mass. In the present study, we investigated the difference in urinary proteomic profile of subjects that recovered (R) and incompletely recovered (IR) from CAAKI, 4 months after hospital discharge. This study helped in identifying potential proteins and associated pathways that are either upregulated or downregulated at the time of hospital discharge in incompletely recovered CAAKI patients that can be further investigated to check for their exact role in the disease progression or repair.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr. Ashok Kumar Yadav

PROVIDER: MSV000095489 | MassIVE | Wed Jul 31 04:28:00 BST 2024

REPOSITORIES: MassIVE

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