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Tear proteome of patients with non-infectious uveitis responders and non-responders to adalimumab

ABSTRACT: Proteomic anaysis of tear samples from patients with non-infectious uveitis responders and non-responders to adalimumab included in a cross-sectional study

INSTRUMENT(S): TripleTOF 6600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Anxo Fernandez Ferreiro

PROVIDER: MSV000095892 | MassIVE |

REPOSITORIES: MassIVE

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Publications

Potential Prognostic Protein Biomarkers in Tears From Noninfectious Uveitis Patients Under Biologic Treatment as a Prelude to Personalized Medicine.

Rodríguez-Martínez Lorena L Rodríguez-Fernández Carmen Antía CA Rodríguez Lemos Olalla O de Domingo Begoña B García Bru Pere P Mateos Jesús J Fernández-Ferreiro Anxo A

Investigative ophthalmology & visual science 20241101 13

<h4>Purpose</h4>Adalimumab (ADA) is a systemic biological treatment option approved for the treatment of noninfectious uveitis (NIU); however, up to 40% of patients do not respond to the drug, either in a primary or secondary manner. Here, we evaluated the proteomic profile of patients with NIU who fail to ADA to identify proteins implicated in intraocular inflammation, as well as potential biomarkers for treatment response and novel therapeutic targets.<h4>Methods</h4>Cross-sectional observatio ...[more]

PMID: 39540857

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