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Junctophilin 2 (JPH2) and ryanodine receptor 2 (RYR2) protein complex in WT and FKBP12 deficient mice heart

ABSTRACT: To determine if the absence of FKBP12 in cardiac tissue alters JPH2 and RYR2 interactions with other dyadic proteins, we immunoprecipitated JPH2 from hearts of FL, MCK-FKD, MHC-Cre+ only, and MHC-FKD mice.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Sung Yun Jung

PROVIDER: MSV000096593 | MassIVE | Wed Dec 04 12:09:00 GMT 2024

SECONDARY ACCESSION(S): PXD058583

REPOSITORIES: MassIVE

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Junctophilin 2 protein complex in WT and FKBP12 deficient mice heart

Project description:To determine if the absence of FKBP12 in cardiac tissue alters JPH2 interactions with other dyadic proteins, we immunoprecipitated JPH2 from hearts of FL, MCK-FKD, MHC-Cre+ only, and MHC-FKD mice. Specific proteins were identified in the IPs from the FL mice and included JPH2, CASQ2 , SPEG, RYR2, CACNA1c, CACNB2, ESD, CMYA5, and LRRC10.

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