Pathogenesis of focal segmental glomerulosclerosis and minimal change disease

ABSTRACT: Podocyte injury is the hallmark of both focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) and is ultimately reflected in foot process effacement proteinuria. Triggers and pathogenic pathways leading to podocyte cytoskeleton rearrangements are however incompletely explained. Here, we aimed to contribute to the understanding of these pathways using tissue bottom-up proteomic profiling of laser capture micro dissected glomeruli from MCD and FSGS.

INSTRUMENT(S): SYNAPT G2-Si

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Iuga Cristina-Adela  

PROVIDER: MSV000097297 | MassIVE | Wed Mar 12 05:05:00 GMT 2025

SECONDARY ACCESSION(S): PXD061755

REPOSITORIES: MassIVE