Dataset Information

Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

ABSTRACT:

Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations of the intestinal microbiota, but causality remains yet to be established. Here, using unpredictable chronic mild stress (UCMS) as a mouse model of depression, we show that UCMS mice display phenotypic alterations which could be transferred from UCMS donors to naïve recipient mice by fecal microbiota transplantation. The cellular and behavioral alterations observed in recipient mice were accompanied by a decrease in the endocannabinoid (eCB) signaling due to lower peripheral levels of fatty acid precursors of eCB ligands. The adverse effects of UCMS-transferred microbiota were alleviated by selectively enhancing the central eCB or by complementation with a strain of the Lactobacilli genus. Our findings provide a mechanistic scenario for how chronic stress, diet and gut microbiota generate a pathological feed-forward loop that contributes to despair behavior via the central eCB system.

INSTRUMENT(S): Q Exactive

SUBMITTER: Ivo Gomperts Boneca Gregoire Chevalier

PROVIDER: MTBLS121 | MetaboLights | 2021-01-21

REPOSITORIES: MetaboLights

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Dataset's files

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			Action	DRS
	MTBLS121	Other
	FILES	Other
	a_MTBLS121_Method1_POS_1_metabolite_profiling_mass_spectrometry.txt	Txt
	a_MTBLS121_Method2_POS_2_metabolite_profiling_mass_spectrometry.txt	Txt
	a_MTBLS121_Method3_NEG_1_metabolite_profiling_mass_spectrometry.txt	Txt

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Publications

Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system.

Chevalier Grégoire G Siopi Eleni E Guenin-Macé Laure L Pascal Maud M Laval Thomas T Rifflet Aline A Boneca Ivo Gomperts IG Demangel Caroline C Colsch Benoit B Pruvost Alain A Chu-Van Emeline E Messager Aurélie A Leulier François F Lepousez Gabriel G Eberl Gérard G Lledo Pierre-Marie PM

Nature communications 20201211 1

Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations of the intestinal microbiota. Here, using unpredictable chronic mild stress (UCMS) as a mouse model of depression, we show that UCMS mice display phenotypic alterations, which could be transferred from UCMS donors to naïve recipient mice by fecal microbiota transplantation. The cellular and behavioral alterations observed in recipient mice were accompan ...[more]

PMID: 33311466

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