Metabolomics

Dataset Information

0

Physiological and Molecular Dissection of Daily Variance in Exercise Capacity


ABSTRACT: Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity between the early and late part of their active phase. The daytime variance in mice was dependent on exercise intensity and relied on the circadian clock proteins PER1/2. High-throughput gene expression and metabolic profiling of skeletal muscle revealed metabolic pathways that are differently activated upon exercise in a daytime-dependent manner. Remarkably, we discovered that ZMP, an endogenous AMPK activator, is induced by exercise in a time-dependent manner to regulate key steps in glycolytic and fatty acid oxidation pathways and potentially enhance exercise capacity. Overall, we propose that time of day is a major modifier of exercise capacity and associated metabolic pathways.

INSTRUMENT(S): Q Exactive

SUBMITTER: Jonathan Sobel 

PROVIDER: MTBLS145 | MetaboLights | 2019-04-07

REPOSITORIES: MetaboLights

Dataset's files

Source:
altmetric image

Publications

Physiological and Molecular Dissection of Daily Variance in Exercise Capacity.

Ezagouri Saar S   Zwighaft Ziv Z   Sobel Jonathan J   Baillieul Sébastien S   Doutreleau Stéphane S   Ladeuix Benjamin B   Golik Marina M   Verges Samuel S   Asher Gad G  

Cell metabolism 20190418 1


Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exercise capacity between the early and late part of their active phase. The daytime variance in mice was dependent on exercise intensity and relied on the circadian clock proteins PER1/2. High-throughput  ...[more]

Similar Datasets

2019-04-07 | GSE117161 | GEO
2021-06-22 | PXD026461 | Pride
2021-06-16 | GSE178262 | GEO
2023-01-19 | GSE199429 | GEO
2021-04-06 | PXD021056 | Pride
2017-11-23 | MSV000081736 | MassIVE
2019-04-01 | GSE126962 | GEO
2018-05-10 | GSE114188 | GEO
2023-08-22 | PXD038276 | Pride
2010-06-15 | GSE20513 | GEO