Ontology highlight
ABSTRACT: Omega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental diseases in epidemiological studies, but the mechanisms by which a n-3 PUFA dietary imbalance affects CNS development are poorly understood. Active microglial engulfment of synaptic elements is an important process for normal brain development and altered synapse refinement is a hallmark of several neurodevelopmental disorders. Here, we identify a molecular mechanism for detrimental effects of low maternal n-3 PUFA intake on hippocampal development. Our results show that maternal dietary n-3 PUFA deficiency increases microglial phagocytosis of synaptic elements in the developing hippocampus, partly through the activation of 12/15- lipoxygenase (LOX)/12-HETE signaling, which alters neuronal morphology and affects cognition in the postnatal offspring. While women of child bearing age are at higher risk of dietary n-3 PUFA deficiency, these findings provide new insights into the mechanisms linking maternal nutrition to neurodevelopmental disorders.
INSTRUMENT(S): Liquid Chromatography MS -
SUBMITTER: Agnes Nadjar
PROVIDER: MTBLS1952 | MetaboLights | 2020-11-03
REPOSITORIES: MetaboLights
Action | DRS | |||
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MTBLS1952 | Other | |||
FILES | Other | |||
a_MTBLS1952_LC-MS___metabolite_profiling.txt | Txt | |||
i_Investigation.txt | Txt | |||
m_MTBLS1952_LC-MS___metabolite_profiling_v2_maf.tsv | Tabular |
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