Ontology highlight
ABSTRACT:
INSTRUMENT(S): Liquid Chromatography MS - negative - hilic
SUBMITTER: Sanne Verberk
PROVIDER: MTBLS2159 | MetaboLights | 2021-03-05
REPOSITORIES: MetaboLights
Action | DRS | |||
---|---|---|---|---|
MTBLS2159 | Other | |||
FILES | Other | |||
a_MTBLS2159_Set1_LC-MS_NEG_HILIC_metabolite_profiling.txt | Txt | |||
a_MTBLS2159_Set2_LC-MS_NEG_HILIC_metabolite_profiling.txt | Txt | |||
i_Investigation.txt | Txt |
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Baardman Jeroen J Verberk Sanne G S SGS van der Velden Saskia S Gijbels Marion J J MJJ van Roomen Cindy P P A CPPA Sluimer Judith C JC Broos Jelle Y JY Griffith Guillermo R GR Prange Koen H M KHM van Weeghel Michel M Lakbir Soufyan S Molenaar Douwe D Meinster Elisa E Neele Annette E AE Kooij Gijs G de Vries Helga E HE Lutgens Esther E Wellen Kathryn E KE de Winther Menno P J MPJ Van den Bossche Jan J
Nature communications 20201208 1
Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here, we show ATP citrate lyase (Acly) to be activated in inflammatory macrophages and human atherosclerotic plaques. We demonstrate that myeloid Acly deficiency induces a stable plaque phenotype characteri ...[more]