Dataset Information

Lipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals

ABSTRACT:

The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized. Liquid chromatography coupled to tandem mass spectrometry was applied to detect the global lipidome in the fasting plasma of 293 Chinese individuals, including 114 T2D patients, 81 prediabetic subjects and 98 individuals with normal glucose tolerance (NGT). Both qualitative and quantitative analyses revealed a gradual change in plasma lipid features with T2D patients exhibiting characteristics close to those of prediabetic individuals, whereas they differed significantly from individuals with NGT. We constructed and validated a random forest classifier with 28 lipidomic features that effectively discriminated T2D from NGT or prediabetes. Most of the selected features significantly correlated with diabetic clinical indices. Hydroxybutyrylcarnitine was positively correlated with fasting plasma glucose, 2-hour postprandial glucose, glycated hemoglobin and insulin resistance index (HOMA-IR). Lysophosphatidylcholines such as lysophosphatidylcholine (18:0), lysophosphatidylcholine (18:1) and lysophosphatidylcholine (18:2) were all negatively correlated with HOMA-IR. The altered plasma lipidome in Chinese T2D and prediabetic subjects suggests that lipid features may play a role in the pathogenesis of T2D and that such features may provide a basis for evaluating risk and monitoring disease development.

INSTRUMENT(S): Xevo G2 QTOF (Waters)

SUBMITTER: Yanqun Fan

PROVIDER: MTBLS352 | MetaboLights | 2017-04-26

REPOSITORIES: MetaboLights

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Dataset's files

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			Action	DRS
	MTBLS352	Other
	FILES	Other
	a_MTBLS352_neg_metabolite_profiling_mass_spectrometry.txt	Txt
	a_MTBLS352_pos_metabolite_profiling_mass_spectrometry.txt	Txt
	a_mtbls352_metabolite_profiling_mass_spectrometry.txt	Txt

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Lipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic, and type 2 diabetic individuals.

Zhong Huanzi H Fang Chao C Fan Yanqun Y Lu Yan Y Wen Bo B Ren Huahui H Hou Guixue G Yang Fangming F Xie Hailiang H Jie Zhuye Z Peng Ye Y Ye Zhiqiang Z Wu Jiegen J Zi Jin J Zhao Guoqing G Chen Jiayu J Bao Xiao X Hu Yihe Y Gao Yan Y Zhang Jun J Yang Huanming H Wang Jian J Madsen Lise L Kristiansen Karsten K Ni Chuanming C Li Junhua J Liu Siqi S

GigaScience 20170701 7

PMID: 28505362

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